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cas 86639  (MedChemExpress)


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    MedChemExpress cas 86639
    Cas 86639, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cas 86639/product/MedChemExpress
    Average 95 stars, based on 65 article reviews
    cas 86639 - by Bioz Stars, 2026-02
    95/100 stars

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    Results of analysis of human cancer cell lines and peripheral blood lymphocytes viability after 72 h exposure to CPT-11, SN38 and CAPE at different concentrations compared to untreated control cells.

    Journal: Molecules

    Article Title: Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

    doi: 10.3390/molecules25030658

    Figure Lengend Snippet: Results of analysis of human cancer cell lines and peripheral blood lymphocytes viability after 72 h exposure to CPT-11, SN38 and CAPE at different concentrations compared to untreated control cells.

    Article Snippet: Irinotecan hydrochloride trihydrate (CPT-11, CAS No. 100286-90-6), 7-Ethyl-10-hydroxycamptothecin (SN38, CAS No. 86639-52-3), DMSO (dimethyl sulfoxide), DAPI (4,6-diamidino-2-phenylindole), MTT [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], Histopaque 1077, were obtained from Sigma Chemicals Co. (St. Louis, MO, United States).

    Techniques:

    The effect of SN38 and co-treatment CAPE+SN38 on HCT116 cells ( A ), HT29 cells ( B ), AGS cells ( C ) and PBLs ( D ) growth after 72 h incubation evaluated by MTT assay (the mean ± SEM) Treatment of CAPE and SN38 simultaneously shows antagonistic effect on cytotoxicity of HT29, HCT116, AGS cells and PBLs. The figure under the graph show the ratio of expected cell number/observed cell number. Factor < 1 represents antagonistic effect CAPE on SN38.

    Journal: Molecules

    Article Title: Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

    doi: 10.3390/molecules25030658

    Figure Lengend Snippet: The effect of SN38 and co-treatment CAPE+SN38 on HCT116 cells ( A ), HT29 cells ( B ), AGS cells ( C ) and PBLs ( D ) growth after 72 h incubation evaluated by MTT assay (the mean ± SEM) Treatment of CAPE and SN38 simultaneously shows antagonistic effect on cytotoxicity of HT29, HCT116, AGS cells and PBLs. The figure under the graph show the ratio of expected cell number/observed cell number. Factor < 1 represents antagonistic effect CAPE on SN38.

    Article Snippet: Irinotecan hydrochloride trihydrate (CPT-11, CAS No. 100286-90-6), 7-Ethyl-10-hydroxycamptothecin (SN38, CAS No. 86639-52-3), DMSO (dimethyl sulfoxide), DAPI (4,6-diamidino-2-phenylindole), MTT [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], Histopaque 1077, were obtained from Sigma Chemicals Co. (St. Louis, MO, United States).

    Techniques: Incubation, MTT Assay

    Viability and caspase-3/7 activity after 24 h ( a ) and 72 h ( b ) of exposure on CAPE, CPT-11, CAPE + CPT-11, SN38 and CAPE + SN38 in AGS, HCT116 and HT29 cell line (mean ± S.E.M). * p < 0.05 as compared with control (untreated) cells; # p < 0.05 as compared with cells treated drug.

    Journal: Molecules

    Article Title: Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

    doi: 10.3390/molecules25030658

    Figure Lengend Snippet: Viability and caspase-3/7 activity after 24 h ( a ) and 72 h ( b ) of exposure on CAPE, CPT-11, CAPE + CPT-11, SN38 and CAPE + SN38 in AGS, HCT116 and HT29 cell line (mean ± S.E.M). * p < 0.05 as compared with control (untreated) cells; # p < 0.05 as compared with cells treated drug.

    Article Snippet: Irinotecan hydrochloride trihydrate (CPT-11, CAS No. 100286-90-6), 7-Ethyl-10-hydroxycamptothecin (SN38, CAS No. 86639-52-3), DMSO (dimethyl sulfoxide), DAPI (4,6-diamidino-2-phenylindole), MTT [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], Histopaque 1077, were obtained from Sigma Chemicals Co. (St. Louis, MO, United States).

    Techniques: Activity Assay

    DNA damage measured in HCT116 ( A ), HT29 ( B ), AGS ( C ) and PBLs ( D ) as the percentage of DNA in the comet tail in the alkaline version of comet assay incubated 24 h with CAPE in the presence of CPT-11 or SN38 (mean ± S.E.M). * p < 0.05 as compared with control (untreated) cells; # p < 0.05 as compared with cells treated drug.

    Journal: Molecules

    Article Title: Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

    doi: 10.3390/molecules25030658

    Figure Lengend Snippet: DNA damage measured in HCT116 ( A ), HT29 ( B ), AGS ( C ) and PBLs ( D ) as the percentage of DNA in the comet tail in the alkaline version of comet assay incubated 24 h with CAPE in the presence of CPT-11 or SN38 (mean ± S.E.M). * p < 0.05 as compared with control (untreated) cells; # p < 0.05 as compared with cells treated drug.

    Article Snippet: Irinotecan hydrochloride trihydrate (CPT-11, CAS No. 100286-90-6), 7-Ethyl-10-hydroxycamptothecin (SN38, CAS No. 86639-52-3), DMSO (dimethyl sulfoxide), DAPI (4,6-diamidino-2-phenylindole), MTT [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], Histopaque 1077, were obtained from Sigma Chemicals Co. (St. Louis, MO, United States).

    Techniques: Single Cell Gel Electrophoresis, Incubation